The results were consistent with other studies that monocyte immune cells such as B cells, CD4 + T cells, CD8 + T cells, macrophages, and natural killer (NK) cells played a key role in tumor immunity and were also related to tumor prognosis in HNSCC patients (Djaldetti and Bessler, 2014; Tamminga et al., 2020). This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.