CXCL8 and cancer: In addition to inflammatory cells, cancer cells stimulated by F. nucleatum can also produce a variety of inflammatory cytokines, such as IL-6, IL-8, and TNF-α, which are related to activation of the NF-κB pathway (Kostic et al., 2013; Rubinstein Mara et al., 2013; Koi et al., 2018).