Casasanta et al. (2020) treated HCT116 cells with F. nucleatum and detected cytokines in the culture medium. F. nucleatum induced the secretion of IL-8 and CXCL1, which are proinflammatory and prometastatic cytokines. Medium rich in IL-8 and CXCL1 enhanced the migration of uninfected cancer cells in a paracrine manner. However, the deletion of adhesin Fap2 caused F. nucleatum to lose the above functions. The gene discussed is CXCL1; the disease is cancer.