By investigating rat abortion model, the results showed NLRP1 and NLRP3 expression in abortion rat uterus increased (∗P < 0.05, ∗∗P < 0.01), TFR1 and ACSL4 expression increased and GPX4 expression was decreased (∗P < 0.05, ∗∗P < 0.01), that compared with the control group. The gene discussed is GPX4; the disease is abortion.