SIX6 has been connected with various eye malformations including anophthalmia and microphthalmia (Gallardo et al., 1999, 2004), primary open angle glaucoma (POAG) (Iglesias et al., 2014; Carnes et al., 2014; Mohanty et al., 2018), and optic disk anomalies and macular atrophy (Yariz et al., 2015). Here, SIX6 is linked to open-angle glaucoma.