SIX1 and osteosarcoma: SIX1 alone has been shown to be overexpressed in many forms of cancer such as breast (Ford et al., 1998; Coletta et al., 2004; Iwanaga et al., 2012), ovarian (Behbakht et al., 2007), cervical (Sun et al., 2016), Wilms tumor (Wegert et al., 2015), osteosarcoma (Hua et al., 2014; Chao et al., 2017), rhabdomyosarcoma (Yu et al., 2004), and several others (Table 2).