Increased expression of either SIX1 or SIX2 in several cancer types reduced the level of CDH1 through either activating known repressors of CDH1, such as Zeb proteins, or by CDH1 promoter methylation (McCoy et al., 2009; Wang et al., 2014; Li J. W. et al., 2018; Hou et al., 2019). The gene discussed is SIX2; the disease is cancer.