SIX2 overexpression has been identified in the pediatric cancer Wilms tumor (Murphy et al., 2012; Pierce et al., 2014; Walz et al., 2015; Wegert et al., 2015) as well as in renal cell carcinoma (Senanayake et al., 2013; Cheng et al., 2019) and nephroblastoma (Senanayake et al., 2013). This evidence concerns the gene SIX2 and cancer.