Recent studies have confirmed that active Notch signaling were highly expressed in αSMA+ PaSCs, pancreatic intraepithelial neoplasia (PanIN) and tumor cells of mice with advanced pancreatic ductal adenocarcinoma (Plentz et al., 2009; Song and Zhang, 2018). This evidence concerns the gene ACTA1 and pancreatic ductal adenocarcinoma.