It is also worth mentioning that the SNP rs956572 (BCL2) that interacted with SNPs in IGF1R gene in our analysis (Table 2), on itself has been intensively studied for more than a decade, and appears to be broadly involved in aging and AD-related traits (e.g., Salvadore et al., 2009; Uemura et al., 2011; Liu et al., 2013; Chang et al., 2018), which might contribute to its propensity to genetic interactions that influence human lifespan. The gene discussed is BCL2; the disease is Alzheimer disease.