The imbalance caused by the decrease in tolerogenic Foxp3+ regulatory T (Treg) cells and the increase in the production of Th17 cells in the lamina propria pro-inflammatory il-17 leads to the NEC-induced excessive inflammatory response (Weitkamp et al., 2013; Liu et al., 2014; Egan et al., 2016). This evidence concerns the gene IL17A and necrotizing enterocolitis.