GPX4 and myocardial infarction: Proteomic studies found that the down-regulation of myocardial GPX4 expression was detected in the early-stage (1 day) and mid-term (1 week) of myocardial infarction in mice, and inhibition of GPX4 expression or function in an in vitro model can significantly increase ferroptosis of myocardial cells (Park et al., 2019).