AGT and Alzheimer disease: To examine whether KIAA1429 affects the development of AD in vivo, we interfered with KIAA1429 expression in AngII-infused C57BL/6J mice by injecting AAV9 vectors harboring overexpression plasmids (termed as LV-KIAA1429), shRNA (termed as sh-KIAA1429), or corresponding NC through the tail vein and confirmed interference effect by measuring the mRNA and protein levels of KIAA1429 in arterial tissues of mice (Figure 3D).