DGCR8 and hepatocellular carcinoma: The findings of two recent studies that METTL14 suppresses the metastasis of hepatocellular carcinoma by modulating pri-miRNA processing via interacting with DGCR8 (Song et al., 2019), and that METTL3 could positively modulate the pri-miRNA process through interacting with the microprocessor protein DGCR8 (Lai et al., 2019), suggest that m6A modification can influence disease progression by affecting the binding of DGCR8 to pri-miRNAs.