To examine whether KIAA1429 affects the development of AD in vivo, we interfered with KIAA1429 expression in AngII-infused C57BL/6J mice by injecting AAV9 vectors harboring overexpression plasmids (termed as LV-KIAA1429), shRNA (termed as sh-KIAA1429), or corresponding NC through the tail vein and confirmed interference effect by measuring the mRNA and protein levels of KIAA1429 in arterial tissues of mice (Figure 3D). The gene discussed is VIRMA; the disease is Alzheimer disease.