Through elevating the level of DDX6 in KIAA1429-overexpressing HASMCs, HAECs, and AngII-infused mice (Figures 8C,D), we found that the enrichment of DDX6 could partly counteract the effect of pro-proliferative effect on HASMCs, the anti-apoptotic effect on HAECs, and the inhibitory effect on AD progression in mice induced by KIAA1429 overexpression (Figures 8E–I and Supplementary Figure 7E). This evidence concerns the gene AGT and Alzheimer disease.