Through elevating the level of DDX6 in KIAA1429-overexpressing HASMCs, HAECs, and AngII-infused mice (Figures 8C,D), we found that the enrichment of DDX6 could partly counteract the effect of pro-proliferative effect on HASMCs, the anti-apoptotic effect on HAECs, and the inhibitory effect on AD progression in mice induced by KIAA1429 overexpression (Figures 8E–I and Supplementary Figure 7E). The gene discussed is VIRMA; the disease is Alzheimer disease.