For instance, TFEB reduced the sensitivity of LoVo and HeLa cells to doxorubicin by inducing activation of autophagy (Fang L. M. et al., 2017), and it reduced the apoptosis of breast cancer cells in response to doxorubicin by repairing DNA damage (Slade et al., 2020). The gene discussed is TFEB; the disease is breast cancer.