Given that, inhibition of TFEB by gene silencing or drugs can markedly enhance the sensitivity of tumor cells to chemotherapy among glioblastoma, lung cancer, pancreatic cancer, and ovarian cancer through either impairing autophagy flux or inducing mitochondrial apoptosis (Karagounis et al., 2016; He et al., 2018; Mitrakas et al., 2018; Song et al., 2019). The gene discussed is TFEB; the disease is lung cancer.