Phosphorylation by DYRK1B results in the degradation of cyclin D1 and stabilization of p27, leading to G0 arrest, thereby reducing chemosensitivity in many cancers especially in pancreatic cancer (Deng et al., 2009, 2014; Becker, 2012, 2018; Ashford et al., 2014). The gene discussed is DYRK1B; the disease is familial pancreatic carcinoma.