In line with this notion, hypomethylating agents like 5-aza-2′-deoxycytidine (5-AZA) restore RIP3 protein expression in about 70% of the tumor cell lines tested, and could sensitize refractory cell lines to TNFα induced necroptosis as well as to several chemotherapeutic agents in a RIP3-dependent manner (47). This evidence concerns the gene TNF and neoplasm.