Regarding the expression of the molecular effectors of necroptosis in tumors, some studies reported a decreased expression of RIPK3, but not RIPK1, in AML (52, 53), while deficiency of both RIPK3/RIPK1 has been reported in colon cancer as compared to non-malignant adjacent tissues (54). Here, RIPK3 is linked to acute myeloid leukemia.