found progastrin as a potential predictive marker of liver metastasis in CRC by immunohistochemistry (10); other researchers identified HOXD10, SLC13A2, OSM, MMP3, CXCL6, and CXCL8 as liver metastasis-associated hub genes of CRC through bioinformatics (11). This evidence concerns the gene OSM and colorectal carcinoma.