ADAM10 and cancer: While some of the identified biomarkers such as p53 and Ki-67 are shared among many other cancer types (64–68), our systematic review of laryngeal and pharyngeal HNSCC characteristically identified the prognostic significance of Wnt/β-catenin pathway-related markers such as β-catenin, DKK1, ADAM10, and ZFX (Table 1 and Figure 4) (27, 47, 58, 67, 68).