In summary, we analyzed the transcriptomic data of cancers in public databases, and found some new information from differentially expressed genes, especially the upregulated expression of ASF1B gene correlated to the prognosis of thyroid cancer (THCA), and ASF1B is associated with disease prognosis in THCA and can be used as a biomarker for THCA prognosis. This evidence concerns the gene ASF1B and thyroid cancer.