SERPINE1 and central nervous system cancer: Intriguingly, at least in the glioma U87 cell line (27), PAI1 has been shown to be mechanistically regulated in an inverse manner by Cav-1, whereas in prostate cancer PAI1 has been shown to have a positive correlation with Cav-1 (89) and within which the mesenchymal signature phenotype included high expression of Cav-1 and markers of EMT transition inc.