More relevant, Cav-1 is directly activated by hypoxia-inducible factor (HIF) (73) with hypoxia-dependent migration tumour cell lines blocked upon Cav-1 knock-down and some evidence that hypoxia-induced migration and invasion of metastatic cancer cells at least, require HIF1α-dependent induction of Cav-1 expression and src family kinase activation (20). This evidence concerns the gene HIF1A and neoplasm.