CAV1 and neoplasm: We also report higher expression of Cav-1 within endothelial cells of the hyperplastic vessels around necrosis of the tumour; the significance of Cav-1 with the tumour vasculature explored in other cancers (65–68) and with some evidence (74) that Cav-1 can regulate endothelial cell plasticity, however, the functional implication of the up- or downregulation of Cav-1 in angiogenesis and associated tumour growth requires further work in a tumour-specific manner.