Interestingly, recent findings support the function of GLS as a multifaceted protein which was not only involved in glutamate generation, but also in carcinogenesis and cancer progression as GLS2 acts as a transcriptional target of p53 and have been argued to have tumor suppressor properties, and re-expressing it in p53-deficient cells limits malignancy (24). This evidence concerns the gene TP53 and cancer.