There was no significant heterogeneity in the DMFS cohorts (I<sup>2</sup> = 0%, P = 0.497).<h4>Conclusion</h4>EGFR high-expression was significantly associated with poor OS and DFS, which may serve as a prognostic predictor for nasopharyngeal cancer.<h4>Systematic review registration</h4>[https://www.crd.york.ac.uk/PROSPERO], identifier [number CRD42021258457]. This evidence concerns the gene EGFR and nasopharyngeal carcinoma.