In addition, WHO grade IV (p = 0.001), SVZ involvement (p = 0.002), tumor-SVZ distance from 0 to 10 mm (p = 0.02), chemotherapy (p = 0.02), and IDH1 mutation (p = 0.03) served as independent predictors for patient PFS (Table 3). The gene discussed is IDH1; the disease is neoplasm.