In the current study, 15 microenvironment-related markers, including Ki-67, p53, β-catenin, MMP7, E-cadherin, and HIF1-α (for cancer cells) and CD10, podoplanin, FSP 1, PDGFR β, FAP, TNC, ZEB1, and TWIST1 (for CAFs) were used. This evidence concerns the gene TNC and cancer.