Four of the GPCRs, (i) galanin receptor type 1 (GALR1) (ii) GALR2, (iii) tachykinin receptor type 1 (TACR1), and (iv) somatostatin receptor type 1 (SST1) are the most studied and promising therapeutic target in a wide variety of cancer. The gene discussed is GALR1; the disease is cancer.