In addition to the negative regulatory patterns in CRC cells, we identified the complimentary domain between PTEN 3′UTR and miR-425 (+2928 to +2934) or miR-576 (+4371 to +4378) and calculated the cogent MFEs between them (−20.8 and −16.1 kcal/mol), in some detail. Here, PTEN is linked to colorectal carcinoma.