The same research group investigated the role of FAP+ CAFs and mixed cells in the Hepa1-6 hepatoma cell line and observed that relative to FAP- CAFs and mixed cells, the tumor model produced using the FAP+ CAFs mixture has higher proportions of polymorphonuclear myeloid-derived suppressor cells, myeloid-derived suppressor cells, and macrophages, and lower proportions of interferon gamma (IFNγ) IFNγ+CD8+ T-cells. The gene discussed is CD8A; the disease is neoplasm.