Similarly, compared with normal tissues, another typical 2-Cys antioxidant enzyme, peroxiredoxin 2 (PRDX2), is downregulated in melanoma tissues and upregulated in the colon, cervical, lung, and other malignancies (Furuta et al., 2006; Lomnytska et al., 2011; Stresing et al., 2013; Xu et al., 2017). This evidence concerns the gene PRDX2 and melanoma.