Notably, the M-genes with high coefficient values in both A549 and TGF-β models across both A549 and TGF-β models are key regulators/inducers of EMT (FN1, LGALS1, and VIM; Mendez et al., 2010; Griggs et al., 2017; Zhu et al., 2019) or specific activators of migratory behavior in epithelial/cancer cells (TAGLN, TPM2; Lee et al., 2010; Shin et al., 2017). This evidence concerns the gene FN1 and cancer.