For example, two pairs of gene sets, up regulation or down regulation in response to KRAS knockdown (SWEET_KRAS_TARGETS, Figure 7B) and up regulation or down regulation in low-malignancy ovarian cancer relative to control (WAMUNYOKOLI_OVARIAN_CANCER_LMP, Figure 7C), yielded functional spaces similar to E and M genes (Figure 7A) and captured a similar amount of variance explained among non-revertant cells (R2 = 0.48 and 0.49, respectively). This evidence concerns the gene KRAS and ovarian cancer.