Targeting homologs of genes previously implicated in human epilepsy, we observed a significant association for an intronic SNP in the gene RBFOX1, encoding an RNA-binding protein that regulates splicing, including transcripts of other epilepsy candidate genes (e.g., GABRG2, KCNQ2, SCN8A, SLC12A5, and SYN1, among others), and plays a key role in neuronal excitation in the mammalian brain (Gehman et al., 2011). Here, SCN8A is linked to epilepsy.