The polymorphism in the immune genes (PTX3, CX3CR1, CARD9, STAT3, and others, Figure 1) make the host susceptible (Garlanda et al., 2002; Kumar et al., 2018; Vinh, 2019), and defect in interleukins (e.g., IL-4, IL-10) leads to genetic predisposition toward fungal infection (Babula et al., 2005; Choi et al., 2005; Zaas, 2006; Table 1). Here, CARD9 is linked to fungal infectious disease.