Upon Candida infection, individuals with STAT3 mutation result in hyper–immunoglobulin E syndrome (HIES) associated with defective Th17 cell differentiation and characterized by elevated serum IgE (Béziat et al., 2018; Frey-Jakobs et al., 2018; Egri et al., 2021). This evidence concerns the gene STAT3 and candidiasis.