Defect in the CLR Dectin1, encoded by CLEC7A (C-type lectin domain containing 7A) predisposes humans to invasive aspergillosis (IA), chronic mucocutaneous candidiasis (CMC), and recurrent vulvovaginal candidiasis (RVVC) (Reid et al., 2009; Plantinga et al., 2012; Cunha et al., 2018). The gene discussed is DCLK3; the disease is chronic mucocutaneous candidiasis.