Thus, in order to explore the possible associations of FGFs 19, 21, and 23 polymorphisms with AD and AD-related aggression, rs948992 of FGF19, rs11665841, and rs11665896 of FGF21, and rs7955866 and rs11063118 of FGF23 were chosen to evaluate genotypes by using MassARRAY@ system, Michigan alcoholism screening test (MAST) was used to measure the level of AD, and a Chinese version of the Buss–Perry Aggression Questionnaire was used to evaluate the aggressive behavior of subjects in the present study. The gene discussed is FGF21; the disease is alcohol dependence.