Enderli et al., 2016) and sparc (Kang et al., 2008; Rotllant et al., 2008) genes have also been proposed as models for OI replicating human mutations after finding reduced ossification with low bone density or phenotypes in the otoliths, pharyngeal arches, or inner ear. Mutations in human orthologs to all these genes have been described as causes of different types of OI (Mortier et al., 2019). The gene discussed is SPARC; the disease is osteogenesis imperfecta.