These genes as well as inflammatory CCL20, TLR2, CD81 and TNFSF14 had both open promoters in the resting CHD monocytes as well as upregulated gene expression in the LPS-stimulated CHD monocytes, linking open chromatin under resting conditions with CHD to transcriptional LPS responses (Figure 4F). Here, TLR2 is linked to coronary artery disorder.