The DEG from these comparisons showed that genes associated with myeloid inflammatory pathways were upregulated (TNFSF21, MMP2, TLR2, MMP1) while genes associated with adaptive immune activation were downregulated (IL21R, CD40, MAMU-DOA, CCR6) in CHD compared to control monocytes (Supplementary Figures 3C, D). Here, MMP2 is linked to coronary artery disorder.