MMP1 and coronary artery disorder: The DEG from these comparisons showed that genes associated with myeloid inflammatory pathways were upregulated (TNFSF21, MMP2, TLR2, MMP1) while genes associated with adaptive immune activation were downregulated (IL21R, CD40, MAMU-DOA, CCR6) in CHD compared to control monocytes (Supplementary Figures 3C, D).