Increased baseline expression of SOCS3 in subjects with obesity is supposed to instantly hinder the signal transduction of the signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) after a VILI insult, as well as to subsequently alleviate inflammatory cascades. Here, SOCS3 is linked to obesity due to melanocortin 4 receptor deficiency.