Several findings have suggested that both, CD4+ and CD8+ T lymphocytes have a direct relationship with the establishment of the immune response since CD4+ T lymphocytes control viral infection through mechanisms such as: i) the increase in B lymphocyte responses and CD8+ lymphocytes, ii) production of inflammatory and antiviral cytokines, iii) cytotoxicity against infected cells, in addition to stimulating immune memory (33–37). This evidence concerns the gene CD4 and viral infectious disease.