KIR2DL3 and Chagas disease: In addition to the results of this study, the KIR2DS2-C1 activating pair, in the absence of its inhibitory homolog, KIR2DL2, independently of the presence or absence of KIR2DL3, has been shown to constitute a possible risk factor for Chagas disease and CCHD in patients from a population in southern Brazil (27).