Co-expression analyses of cell lineages markers showed that RAS grafts were enriched in exhausted CD8pos T cells (BOS vs. Ras: p = 0.008), whereas a higher amount of exhausted CD4pos T cells and B cells (Pax5pos/TOX pos) was seen in BOS grafts (BOS vs. Ras: p = 0.008; Figures 2A, B and Supplementary Figure 1). This evidence concerns the gene TOX and Buschke-Ollendorff syndrome.