Double IHC staining with PD-1 and CD4 or CD8 showed that PD-1pos/CD8pos T lymphocytes were more abundant in RAS than in BOS lungs (BOS vs. Ras: p = 0.01; Figures 3C, D and Supplementary Figure 7). The gene discussed is PDCD1; the disease is Buschke-Ollendorff syndrome.