CD68 and neoplasm: Particularly it is noteworthy that the iNOS+ and CD68+ cells in the tumors with YB1 treatment was higher than the control group, which may suggest that YB1 could induce anti-tumor effects through improving the infiltration of M1-like macrophages in tumors, though the definition and biological functions of macrophage subpopulations are still under debate (42, 43).