Here, using the Line 19 strain of RSV, we observed steady Alox15 expression 3-6 days after infection, followed by a significant decrease in expression at day 12 p.i. In contrast to Alox15 expression, we observed significantly decreased mRNA transcripts of Ltc4s, mGst3, and Gstm4 – biosynthetic enzymes downstream of Alox15 for PCTR1 synthesis – when viral titers were highest at day 3 p.i. These transcriptional changes and the decreased lung tissue concentrations of protectins suggest that the biosynthetic pathway for protectins was suppressed by RSV in this model. Here, GSTM4 is linked to infection.