In these top 10 proteins, IGF2, IGBP7 and SST were the proteins with large fold changes (FC=4.43, 2.60 and 0.17).Besides, we found that IGF2, IGFBP7 and SST are related to demyelinating disease in previous research (19–21). The gene discussed is IGFBP7; the disease is demyelinating disease.