Moreover, flavonoid kaempferol elevated cytotoxic effects of the TRAIL on human ovarian cancer cells OVCAR-3 and SKOV-3 cells mainly mediated by up-regulation of DR4/5, CHOP, JNK, ERK1/2, p38, and down-regulating Bcl-2, Bcl-Xl, survivin, XIAP, and also c-FLIP. The gene discussed is TNFRSF10A; the disease is ovarian cancer.