Regardless of detecting up-regulated TRAIL messenger RNA and protein expression in LGL leukemia cells, studies have shown that DcR2 is the principal TRAIL receptor in LGL leukemia cells, and also evinced that TRAIL-elicited activation of DcR2 caused augmented NF-κB activation in leukemic LGL cells (54). This evidence concerns the gene TNFRSF10D and T-cell large granular lymphocyte leukemia.