Besides, investigation of the TRAIL effects on non-small cell lung cancer (NSCLC) cell line, NCI-H460, verified tumor cell’s sensitivity to TRAIL, while Bcl-2 overexpression supported a highly TRAIL-resistant phenotype, and thereby evidenced the importance of the mitochondrial pathway in stimulating TRAIL-induced apoptosis. The gene discussed is TNFSF10; the disease is non-small cell lung carcinoma.