CFLAR and ovarian carcinoma: Furthermore, cisplatin can induce TRAIL apoptotic pathway in glioblastoma cells neurospheres by DR5 up-regulation and c-FLIP downregulation (92), and also in ovarian cancer SKOV-3 and TOV-21G cells through up-regulating Bax and caspase 3 expression and down-regulating Bcl-2 expression (93).