AKT1 and neoplasm: Furthermore, assessment of the underlying mechanisms that contribute to acquired resistance to TRAIL in TRAIL-resistant human ovarian cancer cell lines (SKOV-3ip1 and A2780) showed that DR4/5-indued signaling following their bindings to TRAIL undesirably elicits induction of pro-survival factors such as NF-κB, Akt, and ERK(1/2), potentiating tumor cells resistance to TRAIL-mediated apoptosis (71).