Also, our studies with leukemia MOLT-4 cells demonstrated that kaempferol could act as a sensitizer leading to sustained TRAIL-mediated apoptosis in MOLT-4 cells by up-regulating DR4/5 expression, reducing the expression of the NF‐κB subunit, and also down-regulating c-FLIP, X-IAP, and cIAP1 expression (130). The gene discussed is NFKB1; the disease is leukemia.