Likewise, Bcl-xL, a cellular inhibitor of apoptosis 2 (cIAP2) and survivin down-regulating following silencing of zinc finger protein SNAIL, which in turn, sustained HCC cells susceptibility to TRAIL-mediated apoptosis signified the chief role of the anti-apoptotic proteins in the resistance process of tumor cells to TRAIL (38). The gene discussed is BCL2L1; the disease is neoplasm.