TNFSF10 and neoplasm: Although the exact mechanisms contributing to the escape from TRAIL-induced apoptosis and progress of resistance to TRAIL in tumor cells has not yet been found completely, it seems that down-regulating pro-apoptotic proteins and DR4/5, concomitant with up-regulating anti-apoptotic proteins along with activating some signaling axis plays an influential role in this regard (225, 226).