For instance, toosendanin (TSN) as a triterpenoid derivative could render human primary NSCLC cells or NSCLC cell lines susceptible to TRAIL-induce apoptosis in vitro and in vivo largely through DR5 up-regulating and activation of CCAAT/enhancer-binding proteins (C/EBP) involved in endoplasmic reticulum (ER) stress response (122). This evidence concerns the gene TNFRSF10B and non-small cell lung carcinoma.