Indeed, TRAIL-expressing MSCs plus compound C increased apoptosis by improving the expression of Bax accompanied by attenuating anti-apoptotic proteins c-FLIP, XIAP, and Bcl-2 in glioma; on the other hand, intervention promoted caspase-3 cleavage and apoptotic cells in a murine glioma model (208). Here, CASP3 is linked to glioma.