On the other hand, gingerol as a phenol phytochemical ingredient found in fresh ginger could reduce survivin, c-FLIP, Bcl-2, and XIAP expression, and restore pro-apoptotic protein Bax and tBid by producing reactive oxygen species (ROS), enabling TRAIL-mediated apoptosis in TRAIL-resistant glioblastoma cells (132). Here, BAX is linked to glioblastoma.