Studies have shown that resistance of the oral squamous cell carcinoma (OSCC) to TRAIL-induced apoptosis is mediated by RANK ligand (RANKL) activation and subsequent blocking of pro-apoptotic proteins Bad and Bax, highlighting the importance of the pro-apoptotic proteins in TRAIL-induced OSCC tumor cell apoptosis (48). Here, TNFSF10 is linked to oral cavity squamous cell carcinoma.