Genes in this crosstalk include those previously reported to be of functional relevance to nephrolithiasis, such as protein kinase C (PRKCA, PRKCB, and PRKCZ) (43), markers (CD40 and TLR3) (44), and autophagy (MTOR and SQSTM1) (13), thus validating our genetic prioritization at the gene and pathway level. This evidence concerns the gene SQSTM1 and nephrolithiasis.