PRKCA and nephrolithiasis: Genes in this crosstalk include those previously reported to be of functional relevance to nephrolithiasis, such as protein kinase C (PRKCA, PRKCB, and PRKCZ) (43), markers (CD40 and TLR3) (44), and autophagy (MTOR and SQSTM1) (13), thus validating our genetic prioritization at the gene and pathway level.