In univariate analysis, the level of G-CSF (OR = 1.0034, 95% CI 1.0000– 1.0067, p = 0.0475), HGF (OR = 1.0018, 95% CI 1.0001–1.0035, p = 0.0411), IL-10 (OR = 1.1930, 95% CI 1.0349– 1.3752, p = 0.0150), IL-18 (OR = 1.0087, 95% CI 1.0002– 1.0173, p = 0.0460), M-CSF (OR = 1.0541, 95% CI 1.0066– 1.1038, p = 0.0251) and SCGF-β (OR = 1.000, 95% CI 1.000– 1.000, p = 0.0271) were associated with the severity of COVID-19. The gene discussed is CSF3; the disease is COVID-19.