reported that treatment with microcystin-leucine arginine ameliorates PF through suppressed CD206+ M2-like macrophage polarization by blocking EMT and fibroblast-myofibroblast transition (FMT), and also substantial reduction of TGFβ1/Smad signaling in rat pulmonary tissues (34). The gene discussed is TGFB1; the disease is pemphigus foliaceus.