Depletion of Ly49H+ NK cells, which represent an NK subset bearing an activation receptor that can engage MHC (H-2b) on B6AJF1 host tissues, after NK infusion also led to improved tumor control early after tumor development (Figure 6E), suggesting blockade of TNFα-producing or depletion of activated NK cell subsets may help regulate toxicity while preserving GVT responses against NBL. This evidence concerns the gene HLA-C and neoplasm.