- In MS, induces anti-inflammatory phenotype by inhibiting the production of pro-inflammatory cytokines and expression of pro-inflammatory miR-155 in monocyte-derived MФs. (116/1, 164.167/2)- In EAE, decreases CD40 expression and production of TNF in monocyte-derived MФs (178).- In vitro, switches M1 microglia to M2 phenotype (177). Here, CD40 is linked to myeloid sarcoma.