IL27 and myeloid sarcoma: - In MS patients, induces anti-inflammatory phenotype by reducing the production of nitric oxide and in contrast, increasing the expression of BDNF and Ig like transcript-3 in monocyte-derived MФs (166–168).Inhibits infiltration of monocyte-derived MФs into the CNS (169).- In EAE, upregulating IL-27 expression in monocyte-derived MФs leads to Th17 suppression (170)- In vitro, promotes phagocytosis capacity of microglia (126).