- In MS, induces anti-inflammatory phenotype by increasing the production of IL-10 and PDL-1 expression (186).- In EAE, inhibits the migration of monocyte-derived MФs in to the CNS (187, 188).- In vitro, induces anti-inflammatory phenotype in microglia by increasing IL-10 production (187, 189). Here, CD274 is linked to myeloid sarcoma.