However, in this study, we explored the expression level of A-SAA variants in ERA, which has been less described, and of alarmins that have been mainly studied as the heterodimeric calprotectin in serum, but not as monomeric proteins in plasma as recommended by Nordal et al. (44) Above all, we focused on their trend to decrease from baseline in DMARDs-naïve patients after 1 year of treatment, exploring their usefulness as companion markers for monitoring RA activity and the inflammatory process. This evidence concerns the gene SAA2 and rheumatoid arthritis.