The aim of the present study was to characterize the expression of the five different A-SAA variants (SAA1α, SAA1β, SAA1γ, SAA2α, and SAA2β) and S100A8/A9 proteins in a large national cohort of early RA (ERA) patients, in regard to healthy control subjects. Here, IGKV1D-22 is linked to rheumatoid arthritis.