CD4 and HIV infectious disease: Confirmation of the underlying mechanism may in turn yield opportunities for intervention, which may include combining ART with agents that block the CD4+ T-cell effector-to-memory transition to inhibit “stabilization” of proviruses within these cells during this critical period (Goonetilleke et al., 2019) or by therapeutically triggering sequential waves of polyclonal CD4+ T-cell activation (with concomitant enhancement of HIV protein expression) during ART, to mimic the relatively rapid cellular “washout” that occurs during untreated HIV infection (Grossman et al., 2020).