Among the observed somatic mutations, we identified a pathogenic somatic CTNNB1 alteration (NM_001098209.2:exon3:c.133T>G:p.Ser45Ala; variant allele frequency (VAF) 33.6%) in the adrenal adenoma; in the pituitary adenoma, a pathogenic USP8 mutation (NM_001128610.3:exon14:c.2152T>C:p.Ser718Pro; VAF 40.2%) as well as a pathogenic alteration in the glucocorticoid receptor gene NR3C1 (NM_000176.3:exon5:c.1729_1735del:p.Trp577Argfs*15; VAF 31.7%) were observed. The gene discussed is NR3C1; the disease is adrenal cortex adenoma.