DPP4 inhibitors decreased the ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity (E/e’) and increased the ratio of peak early to late diastolic filling velocity (E/A), respectively, in patients with T2DM after acute myocardial infarction (AMI), indicating a beneficial effect on LV diastolic failure (125). Here, DPP4 is linked to type 2 diabetes mellitus.