SFRP1 and obesity due to melanocortin 4 receptor deficiency: Administration of high fat diet to SFRP1 knockout mice disturbs glucose homeostasis, induces inflammation and aberrantly elevates regulators of hepatic gluconeogenesis resulting in exacerbated weight gain, provide a new perspective that SFRP1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity (43).