SFRP5 and obesity due to melanocortin 4 receptor deficiency: Furthermore, the phenotypes of obesity and diabetes in inbred mice with SFRPs homologous genes were significantly different (Table 1), for instance, there was no difference in SFRP5 expression levels in DBA/2J mice fed with high-fat diet, but almost 20 times higher in C57BL/6 mice, indicating that epigenetics regulate the phenotypes of obesity and fat swelling of inbred mice and this needs further investigation (107).