Moreover, advanced age, cardiovascular diseases, hypertension and metabolic diseases such as type 2 diabetes and obesity also lead to further dysfunctions in the renin-angiotensin-aldosterone system (RAAS), likely rendering patients with these underlying comorbidities more susceptible to further repercussions of ACE/ACE2 imbalance (7–9) and references therein]. The gene discussed is ACE; the disease is type 2 diabetes mellitus.