Thus, the lung injury and inflammation caused by the reduced ACE2 levels due to the viral infection, and also by the hypertension, the dyslipidemia and diabetes, may be worsened by ACE genotypes that further increase ACE levels, and hence Ang II levels, such as the GG genotype of rs4341 and rs4343 herein analyzed. This evidence concerns the gene ACE2 and Hypertension.