SLC22A2 and cancer: The molecular mechanisms by which these drugs cross the BLB remain unknown, and different ototoxic drugs use likely different pathways, e.g., the anti-cancer drug cisplatin likely utilizes OCT2 (organic cation transporter 2) and CTR1 (copper transporter 1) transporters (24, 25); while aminoglycoside antibiotics could utilize TRPV1 (transient receptor potential V1) and TRPV4 channels (26–28).